In the present day, the workforce is characterized by its diversity, encompassing various aspects such as gender, race, ethnicity, culture, work style, and notably, age, particularly in Indonesia. However, the high turnover rate among generation Z not only poses a societal concern but also leads to noticeable changes in the e-commerce industry, traditionally known for its high turnover rate. Nevertheless, there s still limited studies which have investigated the factors influencing turnover intention among employees in the Indonesian e-commerce sector with the mediating effect of Job satisfaction specifically for the gen Z. Therefore, this study aims to examine the effects of perceived organizational support and job satisfaction of generation Z employee on Indonesian e-commerce industry. Utilizing a quantitative approach with a questionnaire-based survey, the author collected data from a sample of 268 gen Z employees working in e-commerce company around greater Jakarta area. The partial least square structural equation model (PLS-SEM) were employed for data analysis. The results reveal that there was no significant effect of perceived organization support on turnover intention (TI) among gen Z. Then, job satisfaction had a significant and positive effect on turnover intention. Furthermore, perceived organization support had a significant and positive effect on Job satisfaction. Then, there is a strong positive relationship of perceived organizational support toward turnover intention with job satisfaction as a mediating factor.