Grand challenges" are highly significant yet potentially solvable problems such as urban poverty, insect-borne disease, and global hunger. They affect the vast numbers of individuals in often found ways. Grand challenges are typically complex with unknown solutions and intertwined technical and social elements (Ferraro, Etzion, & Gehman, 2015). They may require working across disciplinary boundaries to solve technical problems, and engaging in political action to resolve social ones. Grand challenges may be discrete with a clear endpoint, like landing a rover on Mars or developing a Zika vaccine, or broad and open-ended, such as curing cancer or eliminating poverty. They may change over time, beginning as primarily technical problems and then shifting to social concerns. Regardless of their specifics, grand challenges are complex, uncertain, and without easy solutions (Ferraro et al., 2015). Grand challenges require novel ideas and unconventional approaches to tackle their complex and evolving mix of technical and social elements. For researchers, addressing grand challenges present extensive theoretical opportunities to reveal new concepts, relationships, and logic of organizing while also advancing social "From the Editor" commentaries have addressed specific types of grand challenges, such as climatic change ( Howard-Grenville, Buckle, Hoskins, & George, 2014) and digital money (Dodgson, Gann, Wladawsky-Berger, Sultan, & George, 2015). In this commentary, we focus on how one methodology - cal approach - inductive methods such as theory building from cases, interpretivist studies, and ethnography - can powerfully address grand-address while also developing strong and insightful theory.